ANTIBODIES
Contributor Information
- Institute University of Cambridge
Tool Details
- Tool name: Anti-MCM5 [A2.7A3.F12.A7]
- Clone: A2.7A3.F12.A7
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IF ; WB
- Description: Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal.
- Immunogen: His-tagged human Mcm5 (amino acids 367582)
- Isotype: IgG2b
- Research area: Genetics
- For Research Use Only
Target Details
- Target: Mini Chromosome Maintenance protein5 (MCM5)
- Target background: Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal.
Application Details
- Application: IF ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
References
- • Rakotomalala et al. 2008. J Biol Chem. 283(42):28729-40. PMID: 18693245.
- • Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.
- • Williams et al. 1998. Proc Natl Acad Sci U S A. 95(25):14932-7. PMID: 9843993.
- • Improved cervical smear assessment using antibodies against proteins that regulate DNA replication.
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