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Contributor Information

  • Institute University of Leicester

Tool Details

  • Tool name: Anti-Talin1 [97H6]
  • Clone: 97H6
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; IF ; IP ; WB
  • Description: Monoclonal antibody for investigation into cell adhesion with no cross reactivity with related talin 2 protein.
  • Immunogen: His-tagged polypeptide containing residues 489-911 of mouse Talin1
  • Immunogen UniProt ID: Q9Y490
  • Isotype: IgG1
  • Research area: Cell biology; Cell signaling and signal transduction
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: Talin 1
  • Target background: Monoclonal antibody for investigation into cell adhesion with no cross reactivity with related talin 2 protein.

Application Details

  • Application: ELISA ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Li et al. 2017. Oncotarget. 8(63):106876-106887. PMID: 29290996.
  •   Bouchet et al. 2016. Elife. 5:. PMID: 27410476.
  •   Debrand et al. 2012. Biochem Biophys Res Commun. 426(2):190-5. PMID: 22925892.
  •   Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.
  •   Praekelt et al. 2012. Eur J Cell Biol. 91(3):180-91. PMID: 22306379.
  •   New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
  •   Liu et al. 2011. Mol Cell Biol. 31(16):3366-77. PMID: 21670148.
  •   Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.
  •   Monkley et al. 2011. Dev Biol. 349(2):494-502. PMID: 21081121.
  •   Endothelial cell talin1 is essential for embryonic angiogenesis.
  •   Kopp et al. 2010. Eur J Cell Biol. 89(9):661-73. PMID: 20605055.
  •   Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.