ANTIBODIES

Contributor Information
- Institute University of Leicester
Tool Details
- Tool name: Anti-Talin1 [97H6]
- Clone: 97H6
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IF ; IP ; WB
- Description: Monoclonal antibody for investigation into cell adhesion with no cross reactivity with related talin 2 protein.
- Immunogen: His-tagged polypeptide containing residues 489-911 of mouse Talin1
- Immunogen UniProt ID: Q9Y490
- Isotype: IgG1
- Research area: Cell biology; Cell signaling and signal transduction
- Myeloma used: NS0
- For Research Use Only
Target Details
- Target: Talin 1
- Target background: Monoclonal antibody for investigation into cell adhesion with no cross reactivity with related talin 2 protein.
Application Details
- Application: ELISA ; IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20ðC frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4ðC
References
- • Li et al. 2017. Oncotarget. 8(63):106876-106887. PMID: 29290996.
- • Bouchet et al. 2016. Elife. 5:. PMID: 27410476.
- • Debrand et al. 2012. Biochem Biophys Res Commun. 426(2):190-5. PMID: 22925892.
- • Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.
- • Praekelt et al. 2012. Eur J Cell Biol. 91(3):180-91. PMID: 22306379.
- • New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
- • Liu et al. 2011. Mol Cell Biol. 31(16):3366-77. PMID: 21670148.
- • Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.
- • Monkley et al. 2011. Dev Biol. 349(2):494-502. PMID: 21081121.
- • Endothelial cell talin1 is essential for embryonic angiogenesis.
- • Kopp et al. 2010. Eur J Cell Biol. 89(9):661-73. PMID: 20605055.
- • Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.