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Contributor Information

  • Institute University of Southampton

Tool Details

  • Tool name: Anti-CD70 [TAN 1-7] mAb
  • Alternate names: CD7 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD27 Ligand; CD27LG; TNFSF7; CD27L; Tumor Necrosis Factor Ligand 8A; Surface Antigen CD7; Ki-24 Antigen; CD7 Antigen; TNLG8A
  • Clone: TAN 1-7
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse
  • Host: Rat
  • Application: ELISA ; FACS ; IF ; Fn
  • Description: Monoclonal antibody directed against CD70 cytokine, capable of blocking the CD70-CD27 interaction involved in B and T cell activation.
  • Immunogen: Recombinant mouse CD70 (extracellular domain, aa residues 41-195)
  • Immunogen UniProt ID: O55237
  • Isotype: IgG2a
  • Research area: Apoptosis and autophagy; Cancer; Immunology; Stem cell biology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: CD70
  • Target background: CD70 is a cytokine that belongs to the tumour necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes and dendritic cells. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 expression is induced upon activation of DCs, indicating that the CD70-CD27 interaction could take place during the activation of naive T cells by DCs. Anti-CD70 is non-depleting and blocks the CD70-CD27 interaction. CD70 expression is thought to play a role in autoimmune disease regulation, and treatment of autoimmune diseases such as rheumatoid arthritis.

Application Details

  • Application: ELISA ; FACS ; IF ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Arora et al. 2014. Immunity. 40(1):105-16. PMID: 24412610.
  • •  A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.
  • •  Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells.
  • •  Taraban et al. 2008. J Immunol. 180(7):4615-20. PMID: 18354184.
  • •  Rowley et al. 2004. J Immunol. 172(10):6039-46. PMID: 15128787.
  • •  Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo.