ANTIBODIES
Contributor Information
- Name Nancy Hogg
- Institute Absolute Antibody ; Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: Anti-S100A8 & S100A9 [5.5] rAb
- Clone: 5.5
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Recombinant
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; FACS ; IHC ; IP ; WB
- Description: S100A8 (MRP-8) and S100A9 (MRP-14) are cytosolic calcium-binding proteins of 8kDa and 14kDa that form a heterodimer. S100A8 and S100A9 are expressed in secretory and inflamed keratinocytes, peripheral blood monocytes, neutrophils and has been described in platelets, dendritic cells and some T cell types. Expression is lost on tissue maturation of monocytes to macrophages. S100A9 may be associated with monocyte and neutrophil activation and the accumulation of these cells in inflammatory sites.
- Immunogen: Acute monocytic leukaemia cells.
- Isotype: IgG1
- Research area: Cell signaling and signal transduction; Immunology
- For Research Use Only
Target Details
- Target: S100A8 (MRP-8) & S100A9 (MRP-14)
- Target background: S100A8 (MRP-8) and S100A9 (MRP-14) are cytosolic calcium-binding proteins of 8kDa and 14kDa that form a heterodimer. S100A8 and S100A9 are expressed in secretory and inflamed keratinocytes, peripheral blood monocytes, neutrophils and has been described in platelets, dendritic cells and some T cell types. Expression is lost on tissue maturation of monocytes to macrophages. S100A9 may be associated with monocyte and neutrophil activation and the accumulation of these cells in inflammatory sites.
Application Details
- Application: ELISA ; FACS ; IHC ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS
- Shipping conditions: Shipping at 4° C
Documentation
Related Tools
References
- • Original hybridoma first published in: Hogg et al. 1989. Eur J Immunol. 19(6):1053-61. PMID: 2666142.
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