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Contributor Information

  • Name Fengyi Wan
  • Institute Johns Hopkins University

Tool Details

  • Tool name: Anti-phospho Sam68, Ser113/117
  • Alternate names: KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, p21 Ras GTPase-activating protein-associated p62, p68
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Rabbit
  • Cancer type: Gynaecologic cancer
  • Molecular weight of the target: 68 kDa
  • Application: IHC ; WB
  • Description: Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-Î?B) complexes and binds to promoters of genomic targets important for human lymphocyte activation.
  • Immunogen: Synthetic peptide (NH2-CAEKD(Sp)LDP(Sp)FTH-COOH)
  • Research area: Apoptosis and autophagy; Cell biology; Cell signaling and signal transduction; Genetics

  • For Research Use Only

Target Details

  • Target: Sam68(Src-associatedduringmitosis,68 kDa)
  • Target molecular weight: 68 kDa
  • Target background: Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-B) complexes and binds to promoters of genomic targets important for human lymphocyte activation.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268.
  • •  Sam68 modulates the promoter specificity of NF-B and mediates expression of CD25 in activated T cells.