ANTIBODIES

Contributor Information
- Name Axel Behrens
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: Anti-RACO1 [5H10]
- Alternate names: Ring Finger Protein 187; RING Domain AP1 Coactivator 1; Protein RNF187; RACO1
- Clone: 5H10
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Mouse ; Rat
- Host: Mouse
- Application: ELISA ; IP ; WB
- Strain: CD1
- Description: RING-domain-containing protein (RACO-1) is a c-Jun co-activator that is regulated by the MEK signalling pathway. RACO-1 is a molecular link between growth factor signalling and AP-1. RACO-1 depletion reduces cellular proliferation and decreases expression of several growth-associated AP-1 target genes such as cdc2, cyclin D1 and hb-egf.
- Immunogen: Single C-terminal immunogenic peptide
- Isotype: IgG1
- Research area: Cell signaling and signal transduction
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: RACO1
- Target background: RING-domain-containing protein (RACO-1) is a c-Jun co-activator that is regulated by the MEK signalling pathway. RACO-1 is a molecular link between growth factor signalling and AP-1. RACO-1 depletion reduces cellular proliferation and decreases expression of several growth-associated AP-1 target genes such as cdc2, cyclin D1 and hb-egf.
Application Details
- Application: ELISA ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
References
- • Davies et al. 2010. Nat Cell Biol. 12(10):963-72. PMID: 20852630.
- • Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.