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Contributor Information

  • Name Axel Behrens
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-RACO1 [5H10]
  • Alternate names: Ring Finger Protein 187; RING Domain AP1 Coactivator 1; Protein RNF187; RACO1
  • Clone: 5H10
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Mouse
  • Application: ELISA ; IP ; WB
  • Strain: CD1
  • Description: RING-domain-containing protein (RACO-1) is a c-Jun co-activator that is regulated by the MEK signalling pathway. RACO-1 is a molecular link between growth factor signalling and AP-1. RACO-1 depletion reduces cellular proliferation and decreases expression of several growth-associated AP-1 target genes such as cdc2, cyclin D1 and hb-egf.
  • Immunogen: Single C-terminal immunogenic peptide
  • Isotype: IgG1
  • Research area: Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: RACO1
  • Target background: RING-domain-containing protein (RACO-1) is a c-Jun co-activator that is regulated by the MEK signalling pathway. RACO-1 is a molecular link between growth factor signalling and AP-1. RACO-1 depletion reduces cellular proliferation and decreases expression of several growth-associated AP-1 target genes such as cdc2, cyclin D1 and hb-egf.

Application Details

  • Application: ELISA ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Davies et al. 2010. Nat Cell Biol. 12(10):963-72. PMID: 20852630.
  •   Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.