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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-MMP2 [4D3]
  • Clone: 4D3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: MMP2 degrades type IV collagen and plays an important role in menstrual break down, regulation of vascularization, angiogenesis, and inflammatory response. Mutations of MMP2 are associated with Torg-Winchester syndrome.
  • Immunogen: Ovalbumin-conjugated synthetic peptide; TSLGLPPDVQRVD
  • Isotype: IgG1
  • Research area: Cell biology; Cancer; Tissue-specific biology; Genetics; Metabolism
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Human matrix metalloproteinase 2 (MMP-2)
  • Target background: MMP2 degrades type IV collagen and plays an important role in menstrual break down, regulation of vascularization, angiogenesis, and inflammatory response. Mutations of MMP2 are associated with Torg-Winchester syndrome.

Application Details

  • Application: ELISA ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
  •   The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
  •   Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
  •   Profiling markers of prognosis in colorectal cancer.
  •   Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
  •   Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
  •   Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
  •   Matrix metalloproteinases and their inhibitors in gastric cancer.
  •   Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
  •   Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.