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Contributor Information

  • Name Patrick Varga-Weisz
  • Institute Marie Curie Research Institute

Tool Details

  • Tool name: Anti-WSTF [WSTF]
  • Clone: WSTF
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Rabbit
  • Cancer type: Breast cancer
  • Molecular weight of the target: 170 kDa
  • Application: IF ; IP ; WB
  • Description: The human Williams Syndrome Transcription Factor (WSTF) gene is located within the common Williams Syndrome deletion area at chromosome 7q11.23. Its functional motifs include a PHD zinc finger motif followed by a bromodomain. Both motifs are found in many transcription factors, suggesting that WSTF may function as a transcription factor. WSTF forms a chromatinremodelling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The drosophila Acf1 gene is structurally related to the human WSTF gene.
  • Immunogen: Peptide coupled to keyhole limpet hemocyanin.
  • Research area: Genetics

  • For Research Use Only

Target Details

  • Target: Williams Syndrome Transcription Factor (WSTF)
  • Target molecular weight: 170 kDa
  • Target background: The human Williams Syndrome Transcription Factor (WSTF) gene is located within the common Williams Syndrome deletion area at chromosome 7q11.23. Its Fn motifs include a PHD zinc finger motif followed by a bromodomain. Both motifs are found in many transcription factors, suggesting that WSTF may function as a transcription factor. WSTF forms a chromatinremodelling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The drosophila Acf1 gene is structurally related to the human WSTF gene.

Application Details

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: Whole serum
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Sarshad et al. 2013. PLoS Genet. 9(3):e1003397. PMID: 23555303.
  • •  Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression.
  • •  Bozhenok et al. 2002. EMBO J. 21(9):2231-41. PMID: 11980720.
  • •  WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.