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Anti-PLA2R [12-6-5]

Cat. #152570

Tool name: Anti-PLA2R [12-6-5]
Clone: [12-6-5]
Tool type: Antibodies
Tool sub-type: Primary Antibody
Class: Monoclonal
Conjugate: Unconjugated
Reactivity: Human
Host: Mouse
Application: FACS ; IHC ; IF ; WB
Description: Monoclonal antibody which detects PLA2R, the major antigen for idiopathic membranous nephropathy. Background and Research Application PLA2R is the major auto-antigen in the autoimmune kidney disease, membranous nephropathy. Detection of PLA2R antigen by IHC in the immune complexes present in the glomerular basement membrane is used as a diagnostic marker for the disease. PLA2R is also involved in clearance followed by suppression of their potent enzymatic activities of secretory phospholipase A2 (sPLA2) from the blood, including group sPLA2-X and a snake venom sPLA2. PLA2R acts a tumour suppressor protein and it is associated with cell senescence and differentiated cells.
Immunogen: Human PLA2R extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3). Genbank acc no. U17033; amino acids 20-663 Recombinant protein expressed in HEK 293-EBNA-1 cells
Immunogen UniProt ID: Q13018
Isotype: IgG2b
Research area: Tissue-specific biology; Cell signaling and signal transduction; Metabolism
Myeloma used: Sp2/0-Ag14

Target: Phospholipase A2 receptor 1
Target background: Monoclonal antibody which detects PLA2R, the major antigen for idiopathic membranous nephropathy. Background and Research Application PLA2R is the major auto-antigen in the autoimmune kidney disease, membranous nephropathy. Detection of PLA2R antigen by IHC in the immune complexes present in the glomerular basement membrane is used as a diagnostic marker for the disease. PLA2R is also involved in clearance followed by suppression of their potent enzymatic activities of secretory phospholipase A2 (sPLA2) from the blood, including group sPLA2-X and a snake venom sPLA2. PLA2R acts a tumour suppressor protein and it is associated with cell senescence and differentiated cells.

Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20ĂÂ°C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Shipping at 4ĂÂ°C

£ 300
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