ANTIBODIES
Contributor Information
- Institute A*STAR Accelerate Technologies Pte Ltd
Tool Details
- Tool name: Anti-MOAP-1 [4A12]
- Clone: 4A12
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IF ; WB
- Description: MOAP-1, also known as MAP-1 (Modulator of apoptosis-1) was initially identified as a Bax-associating protein from a yeast two-hybrid screen using Bax as bait. MOAP-1 is enriched in mitochondria and appears to be an effector for mediating Bax function in mitochondria. Moreover, in supporting the idea that MOAP-1 may be involved in a tumor suppressor axis, MOAP-1 is found to associate with the tumor suppressor RASSF1A to mediate Bax-dependent apoptosis in response to death receptor activation in tumor cells.
- Immunogen: GST-MOAP-1 (N-terminal) fusion protein
- Isotype: IgG1
- Research area: Apoptosis and autophagy; Cancer
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: Modulator of apoptosis-1
- Target background: MOAP-1, also known as MAP-1 (Modulator of apoptosis-1) was initially identified as a Bax-associating protein from a yeast two-hybrid screen using Bax as bait. MOAP-1 is enriched in mitochondria and appears to be an effector for mediating Bax function in mitochondria. Moreover, in supporting the idea that MOAP-1 may be involved in a tumor suppressor axis, MOAP-1 is found to associate with the tumor suppressor RASSF1A to mediate Bax-dependent apoptosis in response to death receptor activation in tumor cells.
Application Details
- Application: IF ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
.svg)
Unit size: 
.svg)
.svg)
