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Contributor Information

  • Name Caroline Foxton
  • Institute Cancer Research Technology

Tool Details

  • Tool name: Anti-nNav 1.5 [4G8:1G7]
  • Clone: 4G8:1G7
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 180-200 kDa
  • Application: FACS ; IHC ; IF ; WB
  • Strain: CD1
  • Description: Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5.
  • Immunogen: Peptide (14mer) from an extracellular domain of Nav1.5 - VSENIKLGNLSALR
  • Isotype: IgM
  • Research area: Cell biology; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Neonatal Nav1.5 (Voltage gated Sodium Channel Nav1.5)
  • Target molecular weight: 180-200 kDa
  • Target background: Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5.

Application Details

  • Application: FACS ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Vikram et al. 2017. Nat Med. 23(3):361-367. PMID: 28191886.
  • •  Utrilla et al. 2017. Front Physiol. 8:903. PMID: 29184507.
  • •  Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436.
  • •  Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436.
  • •  Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes.