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Contributor Information

  • Name Keith Willison
  • Institute The Institute of Cancer Research

Tool Details

  • Tool name: Anti-TCP1 [23c (CTA-123)]
  • Clone: 23c (CTA-123)
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Chicken ; Dog ; Hamster ; Mouse ; Rat
  • Host: Rat
  • Application: IHC ; IF ; IP ; WB
  • Description: TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin.
  • Immunogen: C-terminal half of the full length murine TCP protein
  • Isotype: IgG2c
  • Research area: Apoptosis and autophagy; Cancer; Cell biology
  • Myeloma used: Y3.AG.1.2.3

  • For Research Use Only

Target Details

  • Target: TCP1 (T-complex polypeptide 1)
  • Target background: TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin.

Application Details

  • Application: IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Lobanova K et al, 2013. PNAS 110(24):9986-91 PMID 23716657
  • •  Sternlicht et al. 1993. Proc Natl Acad Sci U S A. 90(20):9422-6. PMID: 8105476.
  • •  The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo.
  • •  Harrison-Lavoie et al. 1993. EMBO J. 12(7):2847-53. PMID: 8335000.
  • •  A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins.
  • •  Willison et al. 1989. Cell. 57(4):621-32. PMID: 2655925.
  • •  The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes.