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Anti-TIGAR [M2-P4H2]

Cat. #151870

Tool name: Anti-TIGAR [M2-P4H2]
Clone: M2-P4H2
Tool type: Antibodies
Tool sub-type: Primary antibody
Class: Monoclonal
Conjugate: Unconjugated
Reactivity: Human
Host: Mouse
Application: ELISA ; IHC ; IF ; WB
Strain: Balb/c
Description: TIGAR (TP53 (tumor protein 53)-induced glycolysis and apoptosis regulator), also known as C12orf5, is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. TIGAR shares sequence similarity with the bisphosphate domain of the fructose- 2,6-bisphosphate degrading enzyme (fructose bisphosphatase or FBPase) of the glycolysis pathway and can thus lower the intracellular levels of fructose- 2,6-bisphosphate. TIGAR specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. This suggests a role for TIGAR in protecting cells from reactive oxygen species that can be DNA damaging and lead to apoptosis.
Immunogen: Synthetic peptide; IINFEEGREV (amino acids 239-248)
Isotype: IgG1 kappa
Research area: Apoptosis and autophagy; Cancer; Genetics
Myeloma used: P3X63Ag8.653

Target: TP53-induced glycolysis and apoptosis regulator (TIGAR)
Target background: TIGAR (TP53 (tumor protein 53)-induced glycolysis and apoptosis regulator), also known as C12orf5, is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. TIGAR shares sequence similarity with the bisphosphate domain of the fructose-2,6-bisphosphate degrading enzyme (fructose bisphosphatase or FBPase) of the glycolysis pathway and can thus lower the intracellular levels of fructose-2,6-bisphosphate. TIGAR specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. This suggests a role for TIGAR in protecting cells from reactive oxygen species that can be DNA damaging and lead to apoptosis.

£ 300
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