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Contributor Information

  • Name Stephen West
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-XRCC3 [XRCC3 10F1/6] mAb
  • Clone: XRCC3 10F1/6
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 37.8 kDa
  • Application: IHC ; WB
  • Strain: Balb/c
  • Description: X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.
  • Immunogen: His-tagged human XRCC3
  • Isotype: IgG1
  • Research area: Microbiology; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: XRCC3
  • Target molecular weight: 37.8 kDa
  • Target background: X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.94 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Agostini et al. 2015. Cancer Biol Ther. 16(8):1160-71. PMID: 26023803.
  • •  Li et al. 2014. Sci Signal. 7(326):ra47. PMID: 24847116.
  • •  Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
  • •  Identification and purification of two distinct complexes containing the five RAD51 paralogs.
  • •  Masson et al. 2001. Proc Natl Acad Sci U S A. 98(15):8440-6. PMID: 11459987.
  • •  Complex formation by the human RAD51C and XRCC3 recombination repair proteins.
  • •  Tebbs et al. 1995. Proc Natl Acad Sci U S A. 92(14):6354-8. PMID: 7603995.
  • •  Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.