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Contributor Information

  • Name Andy Turnell
  • Institute University of Birmingham

Tool Details

  • Tool name: Anti-APC5 [APC5#4]
  • Alternate names: Anaphase-promoting complex subunit 5; RMC1; YOR249C
  • Clone: APC5#4
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; IP ; WB
  • Strain: C57BL/6
  • Description: APC5 is a component of the anaphase-promoting complex/cyclosome (APC) that regulates cell cycle progression through mitosis and G1. APC5 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. The APC is inactivated by protein kinase A and is activated by CDC20 and Cdh1.
  • Immunogen: GST-human APC5
  • Isotype: IgG1
  • Research area: Cell biology; Biochemistry
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Anaphase-promoting complex subunit 5 (APC5)
  • Target background: APC5 is a component of the anaphase-promoting complex/cyclosome (APC) that regulates cell cycle progression through mitosis and G1. APC5 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. The APC is inactivated by protein kinase A and is activated by CDC20 and Cdh1.

Application Details

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Turnell et al. 2005. Nature. 438(7068):690-5. PMID: 16319895.
  • •  The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.