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Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-HLADR [CR3/43]
  • Clone: CR3/43
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; WB
  • Description: Monoclonal antibody capable of HLA typing, reacting with subregions of class II antigens.
  • Immunogen: Tonsil cells
  • Immunogen UniProt ID: P01903
  • Isotype: IgG1
  • Research area: Immunology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Human Leukocyte Antigen DR (MHC class II)
  • Target background: Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They therefore have a critical role in the initiation of the immune response. CR3/43 may be used for HLA typing. This antibody reacts with the beta-chain of all products of the gene subregions DP, DQ, and DR.

Application Details

  • Application: FACS ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

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  • •  Breshears et al. 2012. J Biol Chem. 287(39):32578-87. PMID: 22833676.
  • •  A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
  • •  Gatter et al. 1982. Semin Oncol. 9(4):517-25. PMID: 6189189.
  • •  The use of monoclonal antibodies for histopathologic diagnosis of human malignancy.
  • •  Gatter et al. 1982. J Clin Pathol. 35(11):1253-67. PMID: 6183295.
  • •  Use of monoclonal antibodies for the histopathological diagnosis of human malignancy.