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Contributor Information

  • Name Julian Gannon
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-Cul1 [AS97.1]
  • Clone: AS97.1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Mouse
  • Molecular weight of the target:
  • Application: IP ; WB ; IP ; WB
  • Description: Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle.
  • Immunogen: Bacterially expressed full length recombinant human culllin 1. (Cul1)
  • Isotype: IgG2a
  • Research area: Apoptosis and autophagy; Cancer; Cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Cullin 1 (Cul1)
  • Target molecular weight:
  • Target background: Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle.

Application Details

  • Application: IP ; WB ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Ang et al. 2012. PLoS Biol. 10(3):e1001290. PMID: 22479149.
  • •  Mao et al. 2011. J Biol Chem. 286(37):32355-65. PMID: 21778237.
  • •  COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
  • •  Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.