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Contributor Information

  • Name Nick Tidman
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-Keratin15 [LHK15]
  • Clone: LHK 15
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Human ; Mouse ; Rat
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IF ; IP ; WB
  • Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes.
  • Immunogen: Peptide sequence of keratin 15 - BSA conjugate
  • Isotype: IgG2a
  • Research area: Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Keratin 15
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes.

Application Details

  • Application: ELISA ; FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: DMEM + 5-10% FCS
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Waseem A et al. 1999. J. Invest. Dermatol. 112:362-9. PMID: 10084315 Porter RM et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530 Inoue K et al. Lab Invest. 2009 Aug
  • •  89(8):844-56. PMID: 19506554