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Contributor Information

  • Name Stephen West
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-DMC1 [2H12/4] mAb
  • Alternate names: Disrupted meiotic cDNA 1 homolog, Disrupted meiotic cDNA 1, yeast homolog of, dJ199H16.1, DMC 1, DMC1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast), DMC1 homologue
  • Clone: 2H12/4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Human ; Mouse
  • Host: Mouse
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: DMC1 is a meiosis-specific homologue of RecA/RAD51 and is an essential component of the meiotic recombination machinery in yeast and higher eukaryotes.
  • Immunogen: human DMC1 protein (expressed as 6xHis fusion in E. coli and band cut out of gel of insoluble pelet)
  • Isotype: IgG2a
  • Research area: Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: DMC1
  • Target background: DMC1 is a meiosis-specific homologue of RecA/RAD51 and is an essential component of the meiotic recombination machinery in yeast and higher eukaryotes.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Lin et al. 2013. PLoS Genet. 9(5):e1003516. PMID: 23717213.
  • •  Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.
  • •  Erenpreisa et al. 2009. Exp Cell Res. 315(15):2593-603. PMID: 19463812.
  • •  The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.
  • •  Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.
  • •  The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.