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Contributor Information

  • Name Paul Crocker
  • Institute University of Dundee

Tool Details

  • Tool name: Anti-SIGLEC1 [HSn 7D2]
  • Alternate names: CD169, Sialoadhesin 1
  • Clone: HSn 7D2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; RIA ; WB
  • Strain: Balb/c
  • Description: The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.
  • Immunogen: Fc fusion protein containing N-terminal 4 domains of human sialoadhesin.
  • Isotype: IgG1
  • Research area: Cell biology; Cancer; Immunology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Sialoadhesin domains 1-4 (SIGLEC1)
  • Target background: The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.

Application Details

  • Application: ELISA ; FACS ; IHC ; RIA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Puryear et al. 2013. PLoS Pathog. 9(4):e1003291. PMID: 23593001.
  • •  Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169.
  • •  Rempel et al. 2008. PLoS One. 3(4):e1967. PMID: 18414664.
  • •  Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity.
  • •  Pack et al. 2008. Immunology. 123(3):438-46. PMID: 17944899.
  • •  DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp.
  • •  Hartnell et al. 2001. Blood. 97(1):288-96. PMID: 11133773.
  • •  Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.
  • •  Steiniger et al. 1997. Immunology. 92(2):307-16. PMID: 9415041.
  • •  The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone.