ANTIBODIES
Contributor Information
- Name Prof Martin Clynes
- Institute Dublin City University
- Primary citation O'Sullivan D, et al. 2017. Br J Cancer. 1326-1335. PMID: 28881357
Tool Details
- Tool name: Anti-AnxA6 [9E1]
- Clone: 9.00E+01
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: No
- Reactivity: Human
- Host: Mouse
- Cancer type: Breast cancer; Pancreatic cancer; Lung cancer
- Disease: Cancer
- Application: WB, IP, IHC, ELISA
- Description: A highly invasive clonal variant of the MDA-MB-435S cell line was used to generate MAb 9E1, which was screened for anti-invasive activity against aggressive cancer cells in vitro.
- Isotype: IgG1
- Research area: Cancer
- For Research Use Only
Target Details
- Target: AnxA6 antigen
- Target background: Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. AnxA6 is suggested to be functionally involved in the invasive phenotype of PDAC and lung squamous cancer in vitro.
Application Details
- Application: WB, IP, IHC, ELISA
Handling
- Storage buffer: PBS with 0.02% azide
- Storage conditions:  -15°C to -25°C
- Shipping conditions: 4°C
Documentation
References
- • O'Sullivan D, et al. 2017. Br J Cancer. 1326-1335. PMID: 28881357
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