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Contributor Information

  • Institute University of Oxford

Tool Details

  • Tool name: Anti-ICAM3 [ICAM 3.2]
  • Alternate names: Intercellular Adhesion Molecule 3; ICAM-3; ICAM-R; CDW5; CD5
  • Clone: ICAM 3.2
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 130
  • Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
  • Description: ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-3 is the major ligand for LFA-1 (CD11a/CD18) in the resting state. ICAM-3 may play a key role in initiating immune responses. ICAM 3.1 and ICAM 3.2 can be used to examine LFA-1/ICAM-3 adhesion.
  • Immunogen: ICAM-3/Fc chimeric fusion protein.
  • Isotype: IgG1 kappa
  • Research area: Cell biology; Cell signaling and signal transduction; Immunology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: ICAM3 (CD50)
  • Target molecular weight: 130
  • Target background: ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-3 is the major ligand for LFA-1 (CD11a/CD18) in the resting state. ICAM-3 may play a key role in initiating immune responses. ICAM 3.1 and ICAM 3.2 can be used to examine LFA-1/ICAM-3 adhesion.

Application Details

  • Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB

Handling

  • Format: Liquid
  • Concentration: 1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Bossy et al. 1995. Eur J Immunol. 25(2):459-65. PMID: 7875209.
  • •  Epitope mapping and Fn properties of anti-intercellular adhesion molecule-3 (CD50) monoclonal antibodies.
  • •  Holness et al. 1995. J Biol Chem. 270(2):877-84. PMID: 7822326.
  • •  Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1.
  • •  Cordell et al. 1994. J Clin Pathol. 47(2):143-7. PMID: 8132828.
  • •  Cellular distribution of human leucocyte adhesion molecule ICAM-3.
  • •  Doussis-Anagnostopoulou et al. 1993. Am J Pathol. 143(4):1040-3. PMID: 8214000.
  • •  ICAM-3 expression on endothelium in lymphoid malignancy.