ANTIBODIES
Contributor Information
- Name Mike Horton
- Institute Queen Mary University of London
Tool Details
- Tool name: Anti-Macrophage marker [5/9]
- Clone: [5/9]
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IHC
- Strain: Balb/c
- Description: Monoclonal antibody capable of detecting osteoclasts and macrophages.
- Immunogen: A cell suspension containing osteoclasts from osteoclastomas.
- Isotype: IgG1
- Research area: Cell biology; Immunology
- Myeloma used: P3X63Ag8.653
- For Research Use Only
Target Details
- Target: Macrophage marker
- Target background: Macrophages are comprised of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. Functions of macrophages include non-specific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors. They also assist with the killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of enzymes and regulatory molecules. Antibody 5/9 may be used as a macrophage cell marker. The antigen is present in osteoclasts and 5/9 may be useful for the identification of osteoclasts in tissues relevant to developmental pathobiology.
Application Details
- Application: IHC
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20Ă°C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.
- • Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.
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