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Contributor Information

  • Name Walter Bodmer
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-APC [Ali 12-28]
  • Clone: Ali 12-28
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Digestive / Gastrointestinal cancer
  • Molecular weight of the target: 310 kDa
  • Application: WB ; ELISA ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: Ali 12-28 may be used for the detection of APC expression and APC mutations.
  • Immunogen: N-terminal APC-MBP fusion protein
  • Isotype: IgG1
  • Research area: Cancer; Tissue-specific biology; Cell biology; Cell signaling and signal transduction; Genetics; Neurobiology; Stem cell biology

  • For Research Use Only

Target Details

  • Target: Adenomatous Polyposis Coli (APC)
  • Target molecular weight: 310 kDa
  • Target background: The adenomatous polyposis coli (APC) tumour suppressor gene is mutated (often by deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and in over 80% of colorectal cancers.

Application Details

  • Application: WB ; ELISA ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Hadjihannas et al. 2012. EMBO Rep. 13(4):347-54. PMID: 22322943.
  • •  Cell cycle control of Wnt/?-catenin signalling by conductin/axin2 through CDC20.
  • •  Valvezan et al. 2012. J Biol Chem. 287(6):3823-32. PMID: 22184111.
  • •  Tanneberger et al. 2011. J Biol Chem. 286(22):19204-14. PMID: 21498506.
  • •  Structural and Fn characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1).
  • •  Arnold et al. 2009. EMBO J. 28(5):500-12. PMID: 19131971.
  • •  The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.
  • •  Efstathiou et al. 1998. Proc Natl Acad Sci U S A. 95(6):3122-7. PMID: 9501226.
  • •  Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells.