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Contributor Information

  • Name Nick Tidman
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Keratin K1 [LHK1]
  • Clone: LHK1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 68 kDa
  • Application: IHC ; WB
  • Strain: Balb/c
  • Description: Reactivity on normal human skin sections is suprabasal up to the tratum corneum in interfollicular epidermis. The suprabasal in the upper outer root sheath are also reactive. Very good marker for suprabasal keratinocytes.
  • Immunogen: 13-amino acid (1 .75-kd) sequence (VRFVSTSYSGVTR) of the K1 polypeptide C terminus
  • Isotype: IgG2a kappa
  • Research area: Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Keratin 1
  • Target molecular weight: 68 kDa
  • Target background: Reactivity on normal human skin sections is suprabasal up to the tratum corneum in interfollicular epidermis. The suprabasal in the upper outer root sheath are also reactive. Very good marker for suprabasal keratinocytes.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Bloor et al. 2003. Am J Pathol. 162(3):963-75. PMID: 12598329.
  • •  Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization.
  • •  Waseem et al. 1999. J Invest Dermatol. 112(3):362-9. PMID: 10084315.
  • •  Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes.
  • •  Machesney et al. 1998. Am J Pathol. 152(5):1133-41. PMID: 9588880.
  • •  Activated keratinocytes in the epidermis of hypertrophic scars.
  • •  Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.
  • •  Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.