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Contributor Information

  • Name Mike Owen
  • Institute Cancer Research UK, Lincoln's Inn Fields Institute
  • Primary citation Viney et al. 1993. Hybridoma. 11(6):701-13. PMID: 1284120.

Tool Details

  • Tool name: Anti-TCR CBeta1 [JOVI.1] mAb
  • Clone: JOVI.1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cell signalling pathway: TCR signalling
  • Application: WB ; FACS ; IHC ; IF ; IP
  • Description: Monoclonal antibody specific for the variable region of T cell receptors in humans. This antibody aids the study of T-cell mediated diseases.

    Anti-TCR CBeta1 [JOVI.1] mAb recognises an epitope on the majority of TCRs.

    Anti-TCR CBeta1 [JOVI.1] mAb is capable of inducing proliferation of peripheral blood T cells.
  • Immunogen: Human HA1.7 TCR beta chain expressed on transgenic mouse cells.
  • Immunogen UniProt ID: P01850
  • Isotype: IgG2a
  • Research area: Cell biology; Immunology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: TCR CBeta1
  • Target background: The T cell receptor is expressed on all mature T cells. The T cell receptor is heterodimer of alpha/beta or gamma/delta chains, expressed on all mature T cells. TCR's recognize antigen peptides bound to MHC molecules, providing the basis of antigen specific response by T cells. Genetic mutations involving the T cell receptor beta locus have been associated with T cell lymphomas. JOVI.1 can be used for studies of T-cell mediated diseases, including autoimmunity and allergy. Antibody JOVI.1 recognised a determinant on the majority of TCRs, staining 50-75% of peripheral blood T cells and T cell lines expressing different V beta regions.

Application Details

  • Application: WB ; FACS ; IHC ; IF ; IP

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  Rossatti et al. 2019. Cells. 8(11):1-13. PMID: 31690048.
  • •  Beck et al. 2018. Hum Vaccin Immunother. 14(12):2864-2873. PMID: 30111232.
  • •  Tesio et al. 2018. Hemasphere. 2(2):e38. PMID: 31723766.
  • •  Risueño et al. 2008. PLoS ONE. 3(3):e1747. PMID: 18320063.
  • •  Chen et al. 2007. J Biol Chem. 282(48):35361-72. PMID: 17897956.
  • •  Gil et al. 2002. Cell. 109(7):901-12. PMID: 12110186.
  • •  Viney et al. 1993. Hybridoma. 11(6):701-13. PMID: 1284120.