EXPERIMENTAL MODELS
Contributor Information
- Name Hamid Rabb
- Institute Johns Hopkins University
Tool Details
- Tool name: Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mouse
- Tool type: Experimental models
- Tool sub-type: Mouse
- Disease: Acute Kidney Injury and Chronic Kidney Disease
- Model description:
- Genetic background and cross history: Keap1F/F mice crossed with CD4-Cre mice.
- Description: This model helps elucidate a novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development. The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and stress pathways, including heme oxygenase. This model has allowed for the indetification of KEAP 1 as factor involved in cyst formation and hydronephrosis during kidney development, which is advantageous for; studying kidney development as well as the role of the KEAP 1 pathway in kidney repair and regeneration.
- Research area: Drug development
- For Research Use Only
Target Details
- Target: Keap1
Application Details
Handling
Documentation
References
- • Noel et al. 2015. J Am Soc Nephrol. 26(12):2989-3000. PMID: 26293820.
.svg)
Availability: 
.svg)
.svg)
