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Contributor Information

  • Name Laxmikant Deshpande
  • Institute Virginia Commonwealth University

Tool Details

  • Tool name: Gulf War Illness Rat
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Gulf War Illness
  • Model description:
  • Phenotype: Gulf War Illness
  • Zygosity: unknown
  • Description: Repeated low-dose organophosphate diisopropyl fluorophosphate (DFP) exposre leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness
  • Production details: Rats were injected s.c. with 400 Âľg/kg DFP once-daily for 5 days
  • Additional notes: Male Sprague-Dawley Rats

  • For Research Use Only

Target Details

  • Target: acetylcholinesterase

Application Details

Handling

Documentation

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References

  • •  Phillips et al. 2019. Toxicol Sci. 169(2):567-578. PMID: 30859209.
  • •  Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness.
  • •  Phillips et al. 2018. Mil Med. 183(suppl_1):552-555. PMID: 29635560.
  • •  Chronic Neurological Morbidities and Elevated Hippocampal Calcium Levels in a DFP-Based Rat Model of Gulf War Illness.
  • •  Phillips et al. 2016. Neurotoxicology. 52:127-33. PMID: 26619911.
  • •  Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness.