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Contributor Information

  • Name Lijun Xia
  • Institute Oklahoma Medical Research Foundation

Tool Details

  • Tool name: Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans double KO mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Spontaneous Colitis-Associated Cancer; Colorectal Cancer; Mucin; MUC2; Ulcerative Colitis; Microbiome
  • Model: Knock-Out
  • Conditional: No
  • Genetic background and cross history: Mice were generated by crossing core-3 intestinal derived O-glycans with core-1 intestinal derived O-glycans
  • Phenotype: Spontaneous colitis-associated colon cancer
  • Zygosity: unknown
  • Strain: C57BL/6
  • Description: Defective intestinal mucin-type O-glycosylation causes colonic mucus barrier breach and subsequent microbiota-mediated activation of caspase1-dependent inflammasomes in colonic epithelial cells which cause spontaneous colitis-associated cancer in mice
  • Research area: Cancer; Cell signaling and signal transduction; Genetics; Immunology
  • Production details: Mice were generated by crossing core-3 intestinal derived O-glycans with core-1 intestinal derived O-glycans

  • For Research Use Only

Target Details

  • Target: Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Bergstrom et al. 2016. Gastroenterology. 151(1):152-164.e11. PMID: 27059389.
  • •  Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.