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Contributor Information

  • Name Michael Coleman
  • Institute Babraham Institute

Tool Details

  • Tool name: Mapt-9A18 phosphodefective Tau Mouse
  • Alternate names: MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Dementia; Alzheimer's disease and other Tauopathies; Tauopathy;
  • Model: Knock-In
  • Model description:
  • Conditional: No
  • Strain: C57BL/6
  • Description: Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9A18 phosphodefective tau knockin mouse expresses phosphodefective tau with 18 alanine substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation. This is a matched counterpart mouse model for the Mapt9E18 phosphomimetic tau knockin mouse which has 18 glutamate substitutions as a model of an inherited taupathy; frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T).
  • Research area: Cell biology; Genetics; Neurobiology

  • For Research Use Only

Target Details

  • Target: Microtubule-associated protein Tau

Application Details

Handling

Documentation

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References

  • •  Gilley J et al. Neurobiol Aging. 2016 Mar
  • •  39:1-18
  • •  PMID: 26923397