EXPERIMENTAL MODELS
Contributor Information
- Name Michael Coleman
- Institute Babraham Institute
Tool Details
- Tool name: Mapt-9E18 phosphomimetic Tau Mouse
- Alternate names: MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau
- Tool type: Experimental models
- Tool sub-type: Mouse
- Disease: Alzheimer's disease; Tauopathies; Parkinsonism
- Model: Knock-In
- Model description:
- Conditional: No
- Strain: C57BL/6
- Description: Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau (MAPT) are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9E18 phosphomimetic tau knockin mouse expresses phosphomimetic tau with 18 glutamate substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation. This is a model of frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T). There is a complementary phosphodefective counterpart mouse that has matched alanine substitutions (Mapt-9A18).
- Research area: Cell biology; Genetics; Neurobiology
- For Research Use Only
Target Details
- Target: Microtubule-associated protein Tau
Application Details
Handling
Documentation
Related Tools
References
- • Gilley J et al. Neurobiol Aging. 2016 Mar
- • 39:1-18
- • PMID: 26923397
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