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Contributor Information

  • Name Steve Watson
  • Institute University of Birmingham

Tool Details

  • Tool name: CLEC2 Floxed KO Mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Platelet aggregation
  • Model description:
  • Conditional: Yes
  • Conditional description: Conditional deletion of CLEC2 was achieved by insertion of loxP sites flanking exons 3 and 4 of the Clec1b gene
  • Genetic background and cross history: Mice were bred as heterozygotes on a mixed C57B1/6 x 129Sv background
  • Zygosity: Clec1b -/-
  • Description: A novel mutant mouse that lacks functional CLEC2 and has been used to investigate the role of CLEC2 in platelet aggregation and thrombus formation. Enables removal of C-type lectin-like receptor type 2 from pertinent cell types when crossed with Cre-recominase expressing mice.
  • Research area: Genetics; Immunology

  • For Research Use Only

Target Details

  • Target: CLEC2

Application Details

Handling

Documentation

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References

  • •  Hughes et al. J Thromb Haemost 2010
  • •  8:2328-32. PMID:20695981. Finney et al. Blood. 2012
  • •  119(7):1747-1756. PMID:22186994