EXPERIMENTAL MODELS
Contributor Information
- Name Owen Sansom
- Institute Cancer Research UK, Glasgow: The Beatson Institute
Tool Details
- Tool name: Villin-Cre Apcfl/+ KRasG12D/+ Mouse
- Alternate names: GTPase KRas K-Ras 2 Ki-Ras c-K-ras c-Ki-ras
- Tool type: Experimental models
- Tool sub-type: Mouse
- Cancer type: Digestive / Gastrointestinal cancer
- Disease: Cancer
- Model: Conditional Knock-Out
- Conditional: Yes
- Cell signalling pathway: Ras/Raf Signalling
- Description: Oncogenic mutations in the K-ras gene occur in 50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-rasD12 allele in the small intestine of adult mice either alone or in the context of Apc deficiency.
- Research area: Cancer; Genetics
- For Research Use Only
Target Details
- Target: KRasG12D
Application Details
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Documentation
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