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Contributor Information

  • Name Roland Wolf ; Colin Henderson
  • Institute University of Dundee

Tool Details

  • Tool name: HRN Nude Mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Conditional: Yes
  • Genetic background and cross history: The hepatic reductase null (HRN) line, which is PORlox/lox::CreALB, was crossed to the ICRF nude mouse. The ultimate experimental mouse is thus PORlox/lox::CreALB::nu/nu, with PORlox/lox::nu/nu as matched controls (the latter are essentially 'ordinary' nude mice, with normal POR expression, and thus normal hepatic P450 activity).
  • Description: A P450 Oxidoreductase hepatic null in nude background (ICRF nude mouse). This mouse has a conditional deletion of POR and may be used in the drug development process to establish role of P450 activity in anti-cancer drug efficacy in vivo.
  • Research area: Cancer; Drug development; Genetics; Metabolism
  • Production details: The hepatic reductase null (HRN) line, which is PORlox/lox::CreALB, was crossed to the ICRF nude mouse. The ultimate experimental mouse is thus PORlox/lox::CreALB::nu/nu, with PORlox/lox::nu/nu as matched controls (the latter are essentially 'ordinary' nude mice, with normal POR expression, and thus normal hepatic P450 activity).

  • For Research Use Only

Target Details

  • Target: P450 Oxidoreductase

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.
  • •  Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.