EXPERIMENTAL MODELS
Contributor Information
- Name Fiona Watt
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: K14MycER Mouse
- Tool type: Experimental models
- Tool sub-type: Mouse
- Disease: Cancer; Telogen effluvium
- Conditional: Yes
- Conditional description: Conditional expression of MycER under Keratin 14 promoter giving tissue-specific epidermal expression
- Genetic background and cross history: A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
- Phenotype: Skin abnormalities (hyperproliferation; hair follicle; sebaceous gland);
- Zygosity:
- Description: In vivo study of Myc activation in skin; in vivo study of skin cell proliferation & differentiation (sebocytes, epidermis)
- Research area: Cancer; Genetics; Stem cell biology
- Production details: A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
- Additional notes:
- For Research Use Only
Target Details
- Target: cMyc protooncogene (Myc) fused with estragen receptor (ER).
Application Details
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Documentation
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