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Contributor Information

  • Name Fiona Watt
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Lupus Mouse
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Disease: Systemic Lupus Erythematosus (SLE); Autoimmune disease
  • Conditional: Yes
  • Conditional description:
  • Genetic background and cross history: An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
  • Phenotype: The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.Inv-IFNg mice demonstrate key features of the lupus pathology:Skin abnormalities;- retarded hair growth, hypopigmentation of hair- extreme age-related erythema (reddening of skin)- flaky and pustular skin lesions, particularly around joints and appendagesDevelopmental abnormalities;- growth retardation- hunched appearance, odd gait- enlarged spleens, shrunken thymusImmune abnormalities;- contact hypersensitivity- autoantibody production, nephritis
  • Zygosity: Heterozygous
  • Strain:
  • Description: Disease model for systemic lupus erythematosus; in vivo study of IFNg expression in skin
  • Research area: Genetics; Immunology
  • Production details: An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
  • Additional notes: The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.Inv-IFNg mice demonstrate key features of the lupus pathology:Skin abnormalities;- retarded hair growth, hypopigmentation of hair- extreme age-related erythema (reddening of skin)- flaky and pustular skin lesions, particularly around joints and appendagesDevelopmental abnormalities;- growth retardation- hunched appearance, odd gait- enlarged spleens, shrunken thymusImmune abnormalities;- contact hypersensitivity- autoantibody production, nephritis

  • For Research Use Only

Target Details

  • Target: Interferon-g (IFNg)

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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