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Contributor Information

  • Name Jihong Bai, PhD
  • Institute Fred Hutichinson Cancer Center

Tool Details

  • Tool name: Anti-TIAM1 [4E7-b1]
  • Clone: 4E7-b1
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: No
  • Reactivity: human; mouse; rat
  • Host: mouse
  • Molecular weight of the target: 178 kDa
  • Application: WB(1:1000), IP
  • Description: T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a protein coding gene, specifically for RAC-1. RAC-1 is a specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. Diseases associated with TIAM1 include lymphoma and Wolf-Hirschhorn Syndrome.
  • Immunogen: Recombinant TIAM1 GEF domain (mouse 1029-1418)

  • For Research Use Only

Target Details

  • Target: TIAM1
  • Target molecular weight: 178 kDa
  • Target background: recombinant T-lymphoma invasion and metasis-inducing protein 1 (TIAM1)

Application Details

  • Application: WB(1:1000), IP

Handling

  • Storage buffer: PBS with 0.02% azide
  • Storage conditions:  -15°C to -25°C
  • Shipping conditions: 4°C

Documentation

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References

  • •  No publication, validated internally