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Contributor Information

  • Name Helmout Modjtahedi
  • Institute Kingston University
  • Primary citation Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437

Tool Details

  • Tool name: Anti-Integrin alpha3 (CD49c) monoclonal antibody [KU44.22B]
  • Clone: KU44.22B
  • Tool type: Antibodies
  • Tool sub-type: Primary antibodies
  • Class: Monoclonal
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Pancreatic cancer
  • Disease: Cancer
  • Molecular weight of the target: 110 kDa
  • Application: ELISA, IHC, IF, IP, WB, FACS
  • Description: MAb KU44.22B inhibits the growth in vitro of Capan-2 cancer cells, increases migration of BxPC-3 and CFPAC-1 cancer cell lines and induces receptor downregulation and internalisation
  • Immunogen: CFPAC-1 cell line
  • Isotype: IgG1 kappa
  • Research area: Cancer

  • For Research Use Only

Target Details

  • Target: Integrin alpha3
  • Target alternate names: CD49c
  • Target molecular weight: 110 kDa
  • Target background: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.

Application Details

  • Application: ELISA, IHC, IF, IP, WB, FACS

Handling

Documentation

References

  •   Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437