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Contributor Information

  • Institute University of Southampton

Tool Details

  • Tool name: Anti-Desmoglein [33-3D]
  • Clone: 33-3D
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Human
  • Host: Mouse
  • Application: EM (EM) ; IHC ; IF ; WB
  • Strain: Balb/c
  • Description: 33-3D is directed against desmoglein in mammalian tissues, tumours and cultured cells.
  • Immunogen: Bovine desmoglein (desmosomal glycoprotein 1) from nasal epidermis
  • Isotype: IgM
  • Research area: Cell biology; Cancer; Cell signaling and signal transduction
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Desmoglein 1 and 2
  • Target background: Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Desmosomes are intercellular adhesive junctions that occur in almost all epithelia and should therefore be useful as epithelial markers in tumour diagnosis.

Application Details

  • Application: EM (EM) ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Krunic et al. 1998. Br J Cancer. 77(8):1275-9. PMID: 9579833.
  • •  Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin.
  • •  Krunic et al. 1996. Acta Derm Venereol. 76(5):394-8. PMID: 8891017.
  • •  Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis.
  • •  Schäfer et al. 1996. Differentiation. 60(2):99-108. PMID: 8641550.
  • •  Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues.
  • •  Vilela et al. 1995. J Cell Sci. 108 ( Pt 4):1743-50. PMID: 7615689.
  • •  A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen.
  • •  Collins et al. 1990. Br J Cancer. 62(5):796-805. PMID: 2123114.
  • •  A study of desmosomes in colorectal carcinoma.
  • •  Vilela et al. 1987. J Pathol. 153(4):365-75. PMID: 3323436.
  • •  Monoclonal antibody to desmosomal glycoprotein 1--a new epithelial marker for diagnostic pathology.