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Contributor Information

  • Institute National Human Genome Research Institute

Tool Details

  • Tool name: Anti-PAX-FOXO1 [PaxF]
  • Alternate names: PFM.2
  • Clone: PaxF
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 105 kDa
  • Application: ChIP ; IHC ; IF ; IP ; WB ; ChIP-seq
  • Strain: Balb/c
  • Description: Alveolar Rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer and cases with fusion oncoproteins PAX7-FOXO1 and PAX3-FOXO1 have a poor prognosis. Determination of the fusion status is important for RMS diagnostics and therapies. This antibody is specific for the PAX3-FOXO1 and PAX7-FOXO1 and therefore is a valuable tool to study the oncogenesis of ARMS
  • Immunogen: KLH conjugated with peptide PF corresponding to the PAX3-FOXO1 translocation region aa 100-117 (TIGNGLSPQNSIRHNLSL) in Freund’s adjuvant
  • Isotype: IgG2b kappa
  • Research area: Cancer
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: The junction region of the PAX3-FOXO1 and the PAX7-FOXO1 fusion proteins
  • Target molecular weight: 105 kDa

Application Details

  • Application: ChIP ; IHC ; IF ; IP ; WB ; ChIP-seq

Handling

  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Azorsa et al. 2021. Mod Pathol. 34(4):748-757. PMID: 33299109.
  • •  Gryder et al. 2017. Cancer Discov. 7(8):884-899. PMID: 28446439.
  • •  Cao et al. 2010. Cancer Res. 70(16):6497-508. PMID: 20663909.
  • •  Khan et al. 1999. Proc Natl Acad Sci U S A. 96(23):13264-9. PMID: 10557309.