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Contributor Information

  • Name Yaacov Hod
  • Institute Stony Brook University

Tool Details

  • Tool name: Anti-DJ-1 [E2-1A]
  • Alternate names: PARK7
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 24 kDa
  • Application: IHC ; WB
  • Description: DJ-1 is a broadly conserved protein among both prokaryotic and eukaryotic cells. It has been identified as playing a diverse role in a range of cellular processes. DJ-1 was originally proposed to be a pro-oncogene, and has since been shown to be expressed at varying levels in breast, non-small cell lung and prostate cancer. It has been demonstrated to paly a role in the regulation of RNA-binding proteins as well as the regulation of testicular androgen receptors and fertilization. In addition, mutations in DJ-1 have been linked to autosomal recessive early-onset familial Parkinson's disease, and have been shown to be a key component of the oxidative stress and ubiquitin-proteasome system response (see Hod, 2004 PMID: 15258905 for additional details).
  • Immunogen: Full length recombinant human DJ-1
  • Isotype: IgM
  • Research area: Cancer; Neurobiology; Apoptosis and autophagy

  • For Research Use Only

Target Details

  • Target: DJ-1
  • Target molecular weight: 24 kDa
  • Target background: DJ-1 is a broadly conserved protein among both prokaryotic and eukaryotic cells. It has been identified as playing a diverse role in a range of cellular processes. DJ-1 was originally proposed to be a pro-oncogene, and has since been shown to be expressed at varying levels in breast, non-small cell lung and prostate cancer. It has been demonstrated to paly a role in the regulation of RNA-binding proteins as well as the regulation of testicular androgen receptors and fertilization. In addition, mutations in DJ-1 have been linked to autosomal recessive early-onset familial Parkinson's disease, and have been shown to be a key component of the oxidative stress and ubiquitin-proteasome system response (see Hod, 2004 PMID: 15258905 for additional details).

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Hod et al. 2004. J Cell Biochem. 92(6):1221-33. PMID: 15258905.
  • •  Hod et al. 1999. J Cell Biochem. 72(3):435-44. PMID: 10022524.