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Contributor Information

  • Name Julian Gannon
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-CyclinB1 [V92.1]
  • Alternate names: CCNB, CCNB1, CCNB1_HUMAN, G2 Mitotic Specific Cyclin B1 Human Entrez Gene ID 891 Human SwissProt P14635 Human Unigene 2396 Human Gene Symbol CCNB1 Human Chromosome Location 5q13.2
  • Clone: V92.1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Hamster ; Human ; Mouse
  • Host: Mouse
  • Molecular weight of the target: 55-62 kDa
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Description: Clone V92.1, recognizes a protein of 55-62kDa, identified as cyclin B1.
  • Immunogen: Hamster Cyclin B1
  • Isotype: IgG1 kappa
  • Research area: Cancer; Cell biology; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Cyclin B1
  • Target molecular weight: 55-62 kDa
  • Target background: Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin B1 is a marker of cell proliferation and a key component of the cell cycle progression machinery. Cyclin B1 may prove to be a prognostic marker in neoplasia. V92.1 may be used to immunoprecipitate active CDK1/cyclin complexes.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Garner et al. 2002. Oncogene. 21(53):8089-104. PMID: 12444545.
  • •  Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
  • •  Minemoto et al. 2001. Exp Cell Res. 262(1):37-48. PMID: 11120603.
  • •  Characterization of adriamycin-induced G2 arrest and its abrogation by caffeine in FL-amnion cells with or without p53.