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Contributor Information

  • Name Alfonso Colombatti ; Maurizio Mongiat ; Roberto Doliana ; Maria Teresa Mucignat
  • Institute National Cancer Institute CRO - Aviano

Tool Details

  • Tool name: Anti-hEMILIN2 [hEMIL2]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Description: Emilin-2 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-2 is larger than Emilin-1 and contains a unique proline-rich domain. It is involved in regulation of the extrinsic apoptotic pathway, by interacting with death receptors DR4 and DR5 and down-modulates the Wnt signalling pathway. EMILIN2 is also involved in the regulation of angiogenesis and elastogenesis
  • Immunogen: Recombinant human Emilin-2 as immunizing antigen; BALB/c mice as host
  • Research area: Extracellular Matrix; Cancer Microenvironment; Cell signaling and signal transduction; Apoptosis and autophagy

  • For Research Use Only

Target Details

  • Target: hEMILIN2
  • Target background: Emilin-2 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-2 is larger than Emilin-1 and contains a unique proline-rich domain. It is involved in regulation of the extrinsic apoptotic pathway, by interacting with death receptors DR4 and DR5 and down-modulates the Wnt signalling pathway. EMILIN2 is also involved in the regulation of angiogenesis and elastogenesis

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Storage conditions: Store at 2 - 8°C or aliquots at -20°C. Avoid repeated freeze-thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Marastoni et al. 2014. J Pathol. 232(4):391-404. PMID: 24374807.
  • •  Mongiat et al. 2010. Neoplasia. 12(4):294-304. PMID: 20360940.
  • •  Mongiat et al. 2007. Mol Cell Biol. 27(20):7176-87. PMID: 17698584.