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Contributor Information

  • Name Alfonso Colombatti ; Roberto Doliana ; Paola Spessotto ; Maria Teresa Mucignat
  • Institute National Cancer Institute CRO - Aviano

Tool Details

  • Tool name: Anti-mEMILIN1 [mEMIL]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse
  • Host: Rat
  • Application: ELISA ; IHC ; IF ; WB
  • Description: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 interacts with the Î?4Î?1 integrin via the C-terminal gC1q domain. It binds pro-TGFB preventing its maturation to mature TGFB in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
  • Immunogen: Recombinant murine Emilin-1 as immunizing antigen; Wistar rat as host
  • Research area: Extracellular Matrix; Cancer

  • For Research Use Only

Target Details

  • Target: mEMILIN1
  • Target background: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 interacts with the a4?1 integrin via the C-terminal gC1q domain. It binds pro-TGFB preventing its maturation to mature TGFB in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.

Application Details

  • Application: ELISA ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Storage conditions: Store at 2 - 8°C or aliquots at -20°C. Avoid repeated freeze-thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Pivetta et al. 2016. Clin Sci (Lond). 130(14):1221-36. PMID: 26920215.
  • •  Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.
  • •  Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.
  • •  Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.
  • •  Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.
  • •  Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.
  • •  Zacchigna et al. 2006. Cell. 124(5):929-42. PMID: 16530041.