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Contributor Information

  • Name BĂŠ Wieringa
  • Institute Radboud University Medical Centre

Tool Details

  • Tool name: Creatine Kinase B (CK-BYK) [2E10]
  • Alternate names: CKBB, creatine phosphokinase, phosphocreatine kinase
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat ; Rabbit
  • Host: Mouse
  • Application: WB ; EM ; IHC ; IF ; WB
  • Strain: Balb/c
  • Description: Creatine kinase, also known as creatine phosphokinase or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate to create phosphocreatine and adenosine diphosphate. Subcellular partitioning of creatine kinase contributes to the formation of patterns in intracellular ATP distribution and the fuelling of cellular processes with a high and sudden energy demand. We have previously shown that brain-type creatine kinase (CK-B) accumulates at the phagocytic cup in macrophages where it is involved in the compartmentalized generation of ATP for actin remodeling.
  • Immunogen: A synthetic 17-mer peptide corresponding to a unique sequence in the amino-terminal region of human creatine kinase B
  • Isotype: IgG2b
  • Research area: Cell biology; Metabolism; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Brain-type creatine kinase
  • Target background: Creatine kinase, also known as creatine phosphokinase or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate to create phosphocreatine and adenosine diphosphate. Subcellular partitioning of creatine kinase contributes to the formation of patterns in intracellular ATP distribution and the fuelling of cellular processes with a high and sudden energy demand. We have previously shown that brain-type creatine kinase (CK-B) accumulates at the phagocytic cup in macrophages where it is involved in the compartmentalized generation of ATP for actin remodeling.

Application Details

  • Application: WB ; EM ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Venter et al. 2015. Eur J Cell Biol. 94(2):114-27. PMID: 25538032.
  • •  Sistermans et al. 1995. Cell Tissue Res. 280(2):435-46. PMID: 7781040.
  • •  de Kok et al. 1995. Mol Cell Biochem. 143(1):59-65. PMID: 7776959.