ANTIBODIES
Contributor Information
- Name Alison Goodall
- Institute University College London (UCL) ; Absolute Antibody
Tool Details
- Tool name: Anti-Factor VIII:c light chain [RFF-VIII:c/5]
- Clone: rRFF-VIII:c/5
- Tool type: Antibodies
- Class: Recombinant
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IF ; WB
- Description: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody may be used for the purification of Factor VIII from normal plasma and cryoprecipitate.
- Immunogen: Purified Human FVIII
- Isotype: IgG1 kappa
- Research area: Tissue-specific biology
- For Research Use Only
Target Details
- Target: Factor VIII:c light chain
- Target background: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody may be used for the purification of Factor VIII from normal plasma and cryoprecipitate.
Application Details
- Application: IF ; WB
Handling
- Format: Liquid
- Concentration: 1mg/ml
- Storage buffer: RPMI + 10% FCS; non-adherent; subculture every 2-3 days; split 1:5
- Storage conditions:
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Goodall AH et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279 Rotblat F et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638 Rotblat F et al. 1985. Biochemistry. 24: 4294-300. PMID: 2413885
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