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Contributor Information

  • Name Edward Chan
  • Institute University of Florida Research Foundation

Tool Details

  • Tool name: Anti-cancer inhibitor of protein phosphotase 2A [2G10-3B5]
  • Alternate names: CIP2A
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Rat ; Mouse
  • Host: Mouse
  • Application: WB ; IHC ; IF
  • Description: CIP2A is an oncoprotein that inhibits PP2A tumor suppressor activity in human malignancies by preventing degredation of c-Myc and regulates the phosphorylation of many oncoproteins. CIP2A is required for malignant cellular growth and tumor formation and is overexpressed in several human cancers: head and neck squamous cell carcimona, colon cancer, gastric cancer, breast cancer, prostate cancer, and lung caner.
  • Immunogen: MAb were generated using the C-terminal third of the recombinant human protein as antigen
  • Isotype: IgG2b kappa
  • Research area: Cancer; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: Cancerous Inhibitor of Protein Phosphatase 2A
  • Target background: CIP2A is an oncoprotein that inhibits PP2A tumor suppressor activity in human malignancies by preventing degredation of c-Myc and regulates the phosphorylation of many oncoproteins. CIP2A is required for malignant cellular growth and tumor formation and is overexpressed in several human cancers: head and neck squamous cell carcimona, colon cancer, gastric cancer, breast cancer, prostate cancer, and lung caner.

Application Details

  • Application: WB ; IHC ; IF

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Li et al. 2008. Clin Cancer Res. 14(12):3722-8. PMID: 18559589.