ANTIBODIES

Contributor Information
- Name Edward Chan
- Institute University of Florida Research Foundation
Tool Details
- Tool name: Anti-cancer inhibitor of protein phosphotase 2A [2G10-3B5]
- Alternate names: CIP2A
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Rat ; Mouse
- Host: Mouse
- Application: WB ; IHC ; IF
- Description: CIP2A is an oncoprotein that inhibits PP2A tumor suppressor activity in human malignancies by preventing degredation of c-Myc and regulates the phosphorylation of many oncoproteins. CIP2A is required for malignant cellular growth and tumor formation and is overexpressed in several human cancers: head and neck squamous cell carcimona, colon cancer, gastric cancer, breast cancer, prostate cancer, and lung caner.
- Immunogen: MAb were generated using the C-terminal third of the recombinant human protein as antigen
- Isotype: IgG2b kappa
- Research area: Cancer; Cell signaling and signal transduction
- For Research Use Only
Target Details
- Target: Cancerous Inhibitor of Protein Phosphatase 2A
- Target background: CIP2A is an oncoprotein that inhibits PP2A tumor suppressor activity in human malignancies by preventing degredation of c-Myc and regulates the phosphorylation of many oncoproteins. CIP2A is required for malignant cellular growth and tumor formation and is overexpressed in several human cancers: head and neck squamous cell carcimona, colon cancer, gastric cancer, breast cancer, prostate cancer, and lung caner.
Application Details
- Application: WB ; IHC ; IF
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4ðC
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References
- • Li et al. 2008. Clin Cancer Res. 14(12):3722-8. PMID: 18559589.