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Anti-IL31

Cat. #158055

Tool name: Anti-IL31
Tool type: Antibodies
Tool sub-type: Primary Antibody
Class: Polyclonal
Conjugate: Unconjugated
Reactivity: Horse
Host: Rabbit
Molecular weight of the target: 17.7 kDa
Application: ELISA ; WB
Description: IL-31 is an inflammatory cytokine that modulates cell-mediated immunity against pathogens. It is produced by activated CD4+ T lymphocytes, in particular activated Th2 helper cells, mast cells, macrophages, and dendritic cells. It's major sites of action are the skin, lung, intestine and the nervous system. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. It was reported when IL-31 is overexpressed in transgenic mice, it results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development. IL-31 and its receptors are also involved in regulating hematopoietic progenitor cell homeostasis. The antibody will elucidate the role of IL-31 in horse and shed further light on its clinical significance.
Immunogen: Ovalbumin-conjugated synthetic peptide
Research area: Cell biology; Immunology

Target: Interleukin 31
Target molecular weight: 17.7 kDa
Target background: IL-31 is an inflammatory cytokine that modulates cell-mediated immunity against pathogens. It is produced by activated CD4+ T lymphocytes, in particular activated Th2 helper cells, mast cells, macrophages, and dendritic cells. It's major sites of action are the skin, lung, intestine and the nervous system. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. It was reported when IL-31 is overexpressed in transgenic mice, it results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development. IL-31 and its receptors are also involved in regulating hematopoietic progenitor cell homeostasis. The antibody will elucidate the role of IL-31 in horse and shed further light on its clinical significance.

£ 300
This fee is applicable only for non-profit organizations

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