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Contributor Information

  • Institute Yale University

Tool Details

  • Tool name: Anti-CD-45 [C455.1F]
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Cancer type: Blood cancer
  • Description: Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the gene can result in severe combined immunodeficiency and multiple sclerosis. This antibody binds to an exon C-dependent epitope of CD45 glycoprotein. This antibody binds to an exon C-dependent epitope of CD45 glycoprotein.
  • Immunogen: P06800
  • Immunogen UniProt ID: P06800
  • Isotype: IgG2a kappa
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: CD45
  • Target background: Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the gene can result in severe combined immunodeficiency and multiple sclerosis. This antibody binds to an exon C-dependent epitope of CD45 glycoprotein.

Application Details

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Bottomly et al. 1989. Eur J Immunol. 19(4):617-23. PMID: 2567241.