ANTIBODIES

Contributor Information
- Institute Yale University
Tool Details
- Tool name: Anti-CD-45 [C455.1F]
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Cancer type: Blood cancer
- Description: Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the gene can result in severe combined immunodeficiency and multiple sclerosis. This antibody binds to an exon C-dependent epitope of CD45 glycoprotein. This antibody binds to an exon C-dependent epitope of CD45 glycoprotein.
- Immunogen: P06800
- Immunogen UniProt ID: P06800
- Isotype: IgG2a kappa
- Research area: Immunology
- For Research Use Only
Target Details
- Target: CD45
- Target background: Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the gene can result in severe combined immunodeficiency and multiple sclerosis. This antibody binds to an exon C-dependent epitope of CD45 glycoprotein.
Application Details
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20ðC frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4ðC
Related Tools
References
- • Bottomly et al. 1989. Eur J Immunol. 19(4):617-23. PMID: 2567241.