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Contributor Information

  • Name Lionel Crawford
  • Institute University of Cambridge

Tool Details

  • Tool name: Anti-HPV16E2 [TVG 271]
  • Clone: TVG 271
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human papilloma virus
  • Host: Mouse
  • Cancer type: Gynaecologic cancer
  • Application: ELISA ; WB ; ELISA ; WB
  • Strain: Balb/c
  • Description: TVG 271 is useful for detection of protein in cervical lesions. TVG 271 completely inhibits E2 binding to E1.
  • Immunogen: Maltose binding protein MBP-E2 (generated from an expression vector in which the E2 ORF was cloned in frame with malE)
  • Isotype: IgG1
  • Research area: Cancer; Microbiology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Human Papilloma virus-16 early protein 2 (HPV16 E2)
  • Target background: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. E1 and E2 are proteins involved in the regulation of viral DNA replication.

Application Details

  • Application: ELISA ; WB ; ELISA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  A deletion in the gene encoding the CD45 antigen in a patient with SCID.
  • •  Hibma et al. 1995. Eur J Biochem. 229(2):517-25. PMID: 7744075.
  • •  The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2.